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Vascular lesions : These are problems with the blood vessels themselves, which could be hereditary or due to chronic kidney or heart disease

The reason gut flora convert berberine into DHB is because, unlike berberine, DHB can pass through intestinal tissue, which enables it to reach the bloodstream

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Instead of focusing on how treatment affects markers of glycemic control, which has not shown benefit, treatments should be based on anticipated reductions in cardiovascular and kidney disease outcomes